Search on: RHO-ASSOCIATED KINASES 
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Descriptor English:   rho-Associated Kinases 
Descriptor Spanish:   Quinasas Asociadas a rho 
Descriptor Portuguese:   Quinases Associadas a rho 
Synonyms English:   rho-Associated Kinase  
Tree Number:   D08.811.913.696.620.682.700.814
D12.644.360.590
D12.776.476.595
Definition English:   A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT CHAIN PHOSPHATASE and LIM KINASES. 
History Note English:   2008 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   52746 
Unique Identifier:   D054460 

Occurrence in VHL: 		 

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